HANG-OVER and energy

Our research team has found the ideal formula to solve this problem. 

 

Vitamin C

Vitamin C (ascorbic acid) is a water-soluble vitamin essential for the proper functioning of the human body. It is involved in the synthesis of collagen, carnitines and neurotransmitters. Most animals can synthesize it, but humans cannot. [1]

 

Vitamin C enables the synthesis of neurotransmitters in the brain, such as dopamine, noradrenalin, adrenalin and serotonin. These molecules, released by neurons, are essential to brain function, helping to improve cognition and combat stress and and fatigue. [2]

 

An extra intake of vitamin C will help limit the deregulation of these neurotransmitters caused by alcohol consumption.

 

Vitamin B6

Vitamin B6 or pyridoxine is one of the essential water-soluble vitamins. It is widely present in our diet. As a coenzyme, vitamin B6 is involved in around a hundred enzymatic reactions, in the biosynthesis of amino acids and neurotransmitters (dopamine, serotonin and noradrenaline). It is an important player in the metabolic energy network. [3]

 

The combination of Vitamins C and B6 promotes the biosynthesis of these neurotransmitters. Noradrenergic neurons neurons (e.g. locus coeruleus) provide a continuous tonic discharge during wakefulness[4].

 

Ginseng

Ginseng (panax ginseng) takes its name from the Latin word panacea which translates directly as " a cure for all illnesses, and a source of longevity, physical strength and resistance".

 

Ginseng is one of the most famous plants to have been used since ancient times, particularly in the Orient, where it is still traditionally consumed. Its many virtues and properties are attributed to the presence of ginsenosides, of which Ginseng comprises some forty variants[5,6].

 

Consumption of ginseng has been shown to have beneficial effects on the central nervous system, particularly on cognitive function, memory and learning capacity[7,8] Rg1 or Rb1 ginsenosides have been shown to improve cognitive performance through their tonic effect[9,10,11].

 

Ginger 

Ginger (Zingiber officinale roscoe) is one of these natural products, and probably the most widely used in the world. The oleoresin derived from the rhizome is composed of 115 bioactives. Gingerol seems to be the main component, although shogaols are also present[12].

 

Ginger has been consumed since ancient times for its tonic properties, as it promotes the secretion of catecholamines and thus tones the body[13. This energy boost will be greatly appreciated in the hours following heavy alcohol consumption. 

The tonic effect of this combination encourages the secretion of the catecholamine adrenalin, creating an energizing effect. 

The combination of vitamins C and B6, ginger and ginseng, therefore, helps reduce fatigue and maintain a normal energy metabolism. 

 

[1] Vitamin C (Ascorbic Acid). Muhammad Abdullah; Radia T. Jamil; Fibi N. Attia. Stats Pearls [Internet]. May 22, 2020.

[2] (Harrison, F. E. A critical review of vitamin C for the prevention of age-related cognitive decline and Alzheimer's disease. J Alzheimers.Dis. 2012

[3] Parra M, Stahl S, Hellmann H. Vitamin B₆ and Its Role in Cell Metabolism and Physiology. Cells. 2018;7(7):84. Published 2018 Jul 22. doi:10.3390/cells7070084

[4] N. Anne-Claire, Pharmacology of the noradrenergic system. N 18 06 2019. 

[5] Ernst E. Panax ginseng: an overview of the clinical evidence. Journal of Ginseng Research. 2010;34(4):259-263.

[6] Choi KT. Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C A Meyer. Acta Pharmacologica Sinica. 2008;29(9):1109–1118.

[7] Attele AS, Wu JA, Yuan CS. Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol. 1999;58:1685-93.

[8] Radad K, Gille G, Moldzio R, Saito H, Rausch WD. Ginsenosides Rb1 and Rg1 effects on mesencephalic dopaminergic cells stressed with glutamate. Brain Res. 2004;1021:41-53. 

[9] Benishin CG, Lee R, Wang LC, Liu HJ. Effects of ginsenoside Rb1 on central cholinergic metabolism. Pharmacology. 1991;42:223-9. 

[10] Yamaguchi Y, Haruta K, Kobayashi H. Effects of ginsenosides on impaired performance induced in the rat by scopolamine in a radial-arm maze. Psychoneuroendocrinology. 1995;20:645-53.

[11] Mook-Jung I, Hong HS, Boo JH, et al. Ginsenoside Rb1 and Rg1 improve spatial learning and increase hippocampal synaptophysin level in mice. J Neurosci Res. 2001;63:509-15.

[12] Jolad et al. 2005

[13] Iwasaki et al. 2006.