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HANG-OVER and Sleep Quality

Melissa officinalis L., comprises more than 20,000 plant species and is used in various traditional medicines around the world. [1]


This plant is traditionally used against mental and CNS disorders, cardiovascular and respiratory problems, various cancers, as well as a memory enhancer, heart tonic, antidepressant, sedative, and antidote. [2,3,4,5,6,7]


Phytochemical research on M. officinalis has revealed the presence of various phytochemicals, including terpenes like rosmarinic acid (monoterpenes, sesquiterpenes, and triterpenes) and phenolic compounds (phenolic acids, flavonoids, and tannins). [8,9] The main active constituents of M. officinalis are volatile compounds (e.g., geranial, neral, citronellal, and geraniol), triterpenes (e.g., ursolic acid and folic acid), and phenolic compounds (e.g., cis and trans isomers of RA, derivatives of caffeic acid, luteolin, naringin, and hesperidin) [10,11,12]



The results of an open prospective pilot study (in stressed volunteers with mild to moderate anxiety and sleep disorders) showed that oral administration of Cyracos (a patented standardized extract of M. officinalis leaves containing over 7% RA and 15% hydroxycinnamic acid derivatives) at a dose of 600mg/day for 15 days significantly reduces anxious manifestations by 18%, improves anxiety-associated symptoms by 15%, and decreases insomnia by 42%. [13]

These results demonstrate that melissa is an interesting ingredient in managing veisalgia.


[1] Amor, I.L.-B., Boubaker, J., Sgaier, M.B., et al., 2009. Phytochemistry and biological activities of Phlomis species.J.Ethnopharmacol.125,183–202.
[2] Cogan, T.,1636.TheHavenofHealth.PrintedByAnneGriffin, Londen,p.39.
[3] Osbaldeston, T.A., 2000. Dioscorides De Materia Medica. IBIDIS Press, Johannesburg, South Africa.
[4] J., Evelyn,1699.Acetaria:ADiscourseOfSallets. http://www.bookrags.com/ ebooks/15517/1.html#gsc.tab¼0.
[5] Dastmalchi, K.,Dorman,H.D.,Oinonen,P.P.,etal.,2008.Chemicalcompositionand in vitro antioxidative activity of a lemon balm (Melissa officinalis L.) extract.LWT FoodSci.Technol.41,391400 
[6] Jorjani, S.E., 1976. Saeedi Sirjani, A.A. (Ed.), Zakhireh Kharazmshahi (A photo print of the manuscript dated 1206 A.D) 3. The lranian Culture Foundation, Tehran, p. 462.
[7] Ibn sina,H.,1984.Resalat fi-alAdviytolQalbiye(Thetreatiseoncardiacdrugs).Al- MaahadalTorathAl-ElmiAl-Arabi,Damascus,pp.221282.
[8] Allahverdiyev,A.,Duran,N.,Ozguven,M.,etal.,2004.Antiviralactivityofthevo- latile oilsof Melissa officinalis L. againstHerpessimplexvirustype-2.Phyto- medicine 11,657661.
[9] Moradkhani, H.,Sargsyan,E.,Bibak,H.,etal.,2010. Melissa officinalis L., avaluable medicine plant:areview.J.Med.PlantsRes.4,27532759.
[10] Argyropoulos, D.,Müller,J.,2014.Changesofessentialoilcontentandcomposition during convectivedryingoflemonbalm(Melissa officinalis L.). Ind.CropsProd. 52, 118124.
[11] Awad,R.,Muhammad,A.,Durst,T.,etal.,2009.Bioassay-guidedfractionationof lemon balm(Melissa officinalis L.) usingan in vitro measure ofGABAtransa- minase activity.Phytother.Res.23,10751081.
[12] Ibragić, S.,Salihović, M.,Tahirović, I.,etal.,2014.Quantification of some phenolic acids in the leaves of Melissa officinalis L. from Turkey and Bosnia.Bull.Chem. Technol.Bosnia Herzeg.42,4750.
[13] Cases, J.,Ibarra,A.,Feuillere,N.,etal.,2011.Pilottrialof Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances.Med.J.Nutr.Metab.4,211218.


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