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HANG-OVER and sleep quality

Melissa Officinalis L.: Natural ally in the treatment of Anxiety Disorders and Insomnia

 

 Discover one of our flagship Hang-over ingredients:

 

Melissa officinalis L., comprises over 20,000 plant species, and is used in traditional medicines throughout the world. [1]

 

This plant is traditionally used for mental and CNS disorders, cardiovascular and respiratory problems, and various cancers, as well as a memory stimulant, cardiac tonic, antidepressant, sleeping aid and antidote. [2,3,4,5,6,7]

 

Phytochemical research on M. officinalis has revealed the presence of various phytochemicals, including terpenes such as rosmarinic acid (mono-terpenes, sesquiterpenes and triterpenes) and phenolic compounds (phenolic acids, flavonoids and tannins). [8,9]

The main active constituents of M. officinalis are volatile compounds (e.g. geranial, neral, ci- tronellal and geraniol), triterpenes (e.g. ursolic acid and folic acid) and phenolic compounds (e.g. cis- and trans-isomers of AR, caffeic acid derivatives, luteolin, naringin and hesperidin) [10,11,12].

 

Its role

 

The results of a prospective open pilot study (in stressed volunteers with mild-to-moderate anxiety and sleep disorders) showed that oral administration of Cyracoss (a proprietary standardized extract of M.officinalis leaves containing over 7% RA and 15% hydroxycinnamic acid derivatives) at a dose of 600mg/day for 15 days significantly reduced anxiety manifestations by 18%, improved anxiety-related symptoms by 15% and reduced insomnia by 42%. [13]

 

These results show that lemon balm is an interesting ingredient in the treatment of veisalgia.

 

[1] Amor,I.L.-B.,Boubaker,J.,Sgaier,M.B.,etal,2009.Phytochemistryandbiological activities of Phlomis species. J.Ethnopharmacol.125,183–202.
[2] Cogan, T.,1636.TheHavenofHealth.PrintedByAnneGriffin, Londen,p.39.
[3] Osbaldeston, T.A., 2000. Dioscorides De Materia Medica. IBIDIS Press, Johannesburg, South Africa.
[4] J., Evelyn,1699.Acetaria:ADiscourseOfSallets. 〈http://www.bookrags.com/ebooks/15517/1.html#gsc.tab¼0.
[5] Dastmalchi,K.,Dorman,H.D.,Oinonen,P.P.,etal,2008.Chemicalcompositionand in vitro antioxidative activity of a lemon balm (MelissaofficinalisL.) extract.LWT - FoodSci .Technol.41,391-400 
[6] Jorjani, S.E., 1976. Saeedi Sirjani, A.A. (Ed.), Zakhireh Kharazmshahi (A photo print of the manuscript dated 1206 A.D) 3. The lranian Culture Foundation, Tehran, p. 462.
[7] Ibn sina,H.,1984.Resalat fi-al-AdviytolQalbiye(Thetreatiseoncardiacdrugs).Al- Maahadal-TorathAl-ElmiAl-Arabi,Damascus,pp.221-282.
[8] Allahverdiyev,A.,Duran,N.,Ozguven,M.,etal.,2004.Antiviralactivityofthevo- latile oilsof MelissaofficinalisL. againstHerpessimplexvirustype-2.Phyto- medicine 11,657-661.
[9] Moradkhani,H.,Sargsyan,E.,Bibak,H.,etal.,2010. MelissaofficinalisL., avaluable medicine plant:areview.J.Med.PlantsRes.4,2753-2759.
[10] Argyropoulos, D.,Müller,J.,2014.Changesofessentialoilcontentandcomposition during convectivedryingoflemonbalm(MelissaofficinalisL.). Ind.CropsProd. 52, 118-124.
[11] Awad,R.,Muhammad,A.,Durst,T.,etal.,2009.Bioassay-guidedfractionationof lemon balm(MelissaofficinalisL.) usingan in vitro measure ofGABAtransa- minase activity.Phytother.Res.23,1075-1081.
[12] Ibragić, S.,Salihović, M.,Tahirović, I.,etal.,2014.Quantificationof some phenolic acids in the leaves of MelissaofficinalisL. from Turkey and Bosnia.Bull.Chem. Technol.Bosnia Herzeg.42,47-50.
[13] Cases, J.,Ibarra,A.,Feuillere,N.,etal.,2011.Pilottrialof MelissaofficinalisL. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances.Med.J.Nutr.Metab.4,211-218.

 

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Well done! It's an excellent product which generally helps you to be up and running the day after a party.
The dosage is a bit difficult to manage: you don't really know when to take 0 or 1 or 2 tablets at bedtime and/or the next morning. I usually take one in the evening and one in the morning, but sometimes that's not enough. I'd have preferred a formula that you take only when you're not feeling well.

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