HANG-OVER and concentration

Problems with memory and concentration the day after drinking are common and problematic, especially for students or those with professional responsibilities.

Rhodiola

Rhodiola rosea L. (R. rosea L.) is also known as Rhodiola, Roseroot, Arctic Root and Golden Root. [1]

In traditional Chinese medicine (TCM), R. rosea L. is used to replenish the qi (vital energy), activating blood circulation, unblocking blood vessels and improving mental function. [2]

The Rhodiola extracts extracts are used as a dietary supplement for athletes, to boost the body's natural resistance, as an "adaptogen to improve physical and mental performance, and combat stress and fatigue. [3]

Several clinical trials have shown that standardized Rhodiola extract improves mental performance and attention in cognitive function in fatigue after single and repeated administration,[4,5,6] and prevents physical, emotional and mental exhaustion in patients with fatigue syndrome.

Its composition includes salidroside, p-tyrosol, rosavin, pyride, rhodiosine and rhodionine, which are the active ingredients of Rhodiola species, but their quantities vary. [8]

Modern pharmacological studies indicate that its extracts can increase neurotransmitter levels, central nervous system activity and cardiovascular function. [9,10]

Ginseng

Ginseng consumption has been shown to have beneficial effects on the central nervous system, and in particular on cognitive function, memory and learning capacity. [11,12]. The ginsenoside Rg1 or Rb1 have been shown toThe ginsenosides Rg1 and Rb1 have been shown to improve cognitive performance.[13,14,15]

Ginseng offers a wide range of therapeutic properties. 

L-Theanine

L-theanine receives special attention particular attention by the scientific community as a modulator of human brain functions.

We speak of modulation of alpha activity, which is applied to tasks requiring attention, with a beneficial effect on mental state. [16,17,18]

The combination of Rhodiola, L-theanine and Ginseng promotes concentration and memory retention.

[1] (Farhath et al., 2005)

[2] (Pharmacopoeia Committee of the Ministry of Health of the People's Republic of China, 2005).

[3]. Panossian A, Wikman G, Sarris J. Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy. Phytomedicine. 2010

[4]. Shevtsov VA, Zholus BI, Shervarly VI, Vol'skij VB, Korovin YP, Khristich MP, Roslyakova NA, Wikman G. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine. 2003

[5]. Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H. Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine. 2000.

[6]. Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine. 2000.

[7] Olsson EM, von Schéele B, Panossian AG. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta Med. 2009

[8] Zhang et al., 2006.

[9] Spasov et al., 2000

[10] Shevtsov et al., 2003

[11] Attele AS, Wu JA, Yuan CS. Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol. 1999;58:1685-93.

[12] Radad K, Gille G, Moldzio R, Saito H, Rausch WD. Ginsenosides Rb1 and Rg1 effects on mesencephalic dopaminergic cells stressed with glutamate. Brain Res. 2004;1021:41-53. 

[13] Benishin CG, Lee R, Wang LC, Liu HJ. Effects of ginsenoside Rb1 on central cholinergic metabolism. Pharmacology. 1991;42:223-9. 

[14] Yamaguchi Y, Haruta K, Kobayashi H. Effects of ginsenosides on impaired performance induced in the rat by scopolamine in a radial-arm maze. Psychoneuroendocrinology. 1995;20:645-53.

[15] Mook-Jung I, Hong HS, Boo JH, et al. Ginsenoside Rb1 and Rg1 improve spatial learning and increase hippocampal synaptophysin level in mice. J Neurosci Res. 2001;63:509-15. [95] Gomez-Ramirez M., Kelly S.P., Montesi J.L., Foxe J.J. The effects of l-theanine on alpha-band oscillatory brain activity during a visuo-spatial attention task. Brain Topogr. 2009;22:44-51.

[16] Nobre A.C., Rao A., Owen G.N. l-theanine, a natural constituent in tea, and its effect on mental state. Asia Pac. J. Clin. Nutr. 2008;17(Suppl. 1):167-168.

[17] Gomez-Ramirez M., Higgins B.A., Rycroft J.A., Owen G.N., Mahoney J., Shpaner M., Foxe J.J. The deployment of intersensory selective attention: A high-density electrical mapping study of the effects of theanine. Clin. Neuropharmacol. 2007;30:25-38.

[18] Turkozu D., Sanlier N. l-theanine, unique amino acid of tea, and its metabolism, health effects, and safety. Crit. Rev. Food Sci. Nutr. 2017;57:1681-1687.[99] Rao T.P., Ozeki M., Juneja L.R. In search of a safe natural sleep aid. J. Am. Coll. Nutr. 2015;34:436-447.