Hang-over-and-energy

Fatigue negatively impacts our day the day after alcohol consumption: failure to meet obligations, procrastination, lethargy, it is clear that our productivity and well-being are affected. 

Our research team has found the ideal formula to address this problem. 

 

Vitamin C

Vitamin C (ascorbic acid) is an essential water-soluble vitamin for the proper functioning of the human body. It is involved in the synthesis of collagen, carnitines, and neurotransmitters. Most animals can synthesize it, but humans cannot. [1]

 

Vitamin C allows the synthesis of neurotransmitters in the brain, such as dopamine, norepinephrine, adrenaline, and serotonin. These molecules released by neurons are essential for the proper functioning of the brain, helping to improve cognition and contributing to combating stress and fatigue. [2]

 

Having an additional intake of vitamin C will help limit the dysregulation of these neurotransmitters caused by alcohol consumption.

 

Vitamin B6

Vitamin B6 or pyridoxine is one of the essential water-soluble vitamins. It is widely present in our diet. As a coenzyme, Vitamin B6 is involved in about a hundred enzymatic reactions, in the biosynthesis of amino acids and neurotransmitters (dopamine, serotonin, and norepinephrine). It is an important actor in the energetic metabolic network. [3]

 

The combination of Vitamins C and B6 helps promote the biosynthesis of these neurotransmitters. Noradrenergic neurons (for example, from the locus coeruleus) offer continuous tonic discharge during wakefulness. [4]

 

Ginseng

Ginseng (Panax ginseng) gets its name from the Latin word panacea, whose direct translation is "a cure for all diseases, and a source of longevity, physical strength, and resistance."

 

Ginseng is one of the famous plants used since antiquity, especially in the East, where it is still traditionally consumed. Its many virtues and properties are attributed to the presence of ginsenosides, of which Ginseng has about forty variants. [5,6]

 

It has been shown that the consumption of ginseng has beneficial effects on the central nervous system, especially on cognitive functions, memory, and learning ability. [7,8] Ginsenosides Rg1 or Rb1 have been highlighted in improving cognitive function for their tonic effect. [9,10,11]

 

Ginger 

Ginger (Zingiber officinale roscoe) is one of these natural products and is probably the most commonly used in the world. The oleoresin from the rhizome consists of 115 bioactives. Gingerol seems to be the major component, although shogaols are also found. [12]

 

Ginger has been consumed since antiquity for its tonic properties as it promotes the secretion of catecholamine and thus tones the body. [13 This energy boost will be greatly appreciated in the hours following heavy alcohol consumption. 

Through its tonic effect, this combination encourages the secretion of adrenaline catecholamine, creating an energizing effect. 

The combination of vitamins C and B6, ginger, and ginseng, therefore contributes to reducing fatigue and maintaining normal energy metabolism.

[1] Vitamin C (Ascorbic Acid). Muhammad Abdullah; Radia T. Jamil; Fibi N. Attia. Stats Pearls [Internet]. May 22, 2020.

[2] (Harrison, F. E. A critical review of vitamin C for the prevention of age-related cognitive decline and Alzheimer's disease. J Alzheimers.Dis. 2012

[3] Parra M, Stahl S, Hellmann H. Vitamin B₆ and Its Role in Cell Metabolism and Physiology. Cells. 2018;7(7):84. Published 2018 Jul 22. doi:10.3390/cells7070084

[4] N. Anne-Claire, Pharmacologie du système noradrénergique. N 18 06 2019. 

[5] Ernst E. Panax ginseng: an overview of the clinical evidence. Journal of Ginseng Research. 2010;34(4):259–263. 

[6] Choi KT. Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C A Meyer. Acta Pharmacologica Sinica. 2008;29(9):1109–1118. 

[7] Attele AS, Wu JA, Yuan CS. Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol. 1999;58:1685–93.

[8] Radad K, Gille G, Moldzio R, Saito H, Rausch WD. Ginsenosides Rb1 and Rg1 effects on mesencephalic dopaminergic cells stressed with glutamate. Brain Res. 2004;1021:41–53. 

[9] Benishin CG, Lee R, Wang LC, Liu HJ. Effects of ginsenoside Rb1 on central cholinergic metabolism. Pharmacology. 1991;42:223–9. 

[10] Yamaguchi Y, Haruta K, Kobayashi H. Effects of ginsenosides on impaired performance induced in the rat by scopolamine in a radial-arm maze. Psychoneuroendocrinology. 1995;20:645–53.

[11] Mook-Jung I, Hong HS, Boo JH, et al. Ginsenoside Rb1 and Rg1 improve spatial learning and increase hippocampal synaptophysin level in mice. J Neurosci Res. 2001;63:509–15.

[12] Jolad et al. 2005

[13] Iwasaki et al. 2006.